#ScienceMediaHype on Growth Hormones
Irene Riz shows why the media reports on billionaire investor Peter Thiel’s growth hormone comments are scientifically inaccurate and irresponsible.
#science #stem #health
Originally shared by Irene Riz
Recently published paper directly shows the role of growth hormone mediated activation of #mTOR in aging (http://www.ncbi.nlm.nih.gov/pubmed/25456069). It supports accumulating studies indicating that inhibition of mTOR by caloric restriction prolongs life and activation of mTOR leads to accelerated aging.
Despite that Peter Thiel takes growth hormone pill every day and plans to live until 120.
“The 47-year-old investor, who co-founded PayPal and made an early bet on Facebook Inc, said he’s taking human growth hormone every day in a wide-ranging interview with Bloomberg Television’s Emily Chang.” http://www.bloomberg.com/news/2014-12-18/investor-peter-thiel-planning-to-live-120-years.html
The only thing he is afraid of is higher chance of cancer for which Mr. Thiel is optimistically expecting to find cure in 10 years. (Biologists can promise anything to get funded, but biology is the most difficult science for future predictions). Cancer apart, premature #stem cell exhaustion is a major problem that is expected if to stimulate mTOR, one of the important downstream targets of growth hormone.
Mr. Thiel somehow missed the point that natural decline of the growth hormone levels and lower mTOR activity might be an approach of a healthy body fighting aging, giving body longer periods for #autophagy mediated self-cleaning and error correction versus active growth and building. In addition, as I already mentioned, an over-activation of mTOR may cause exhaustion of stem cell supplies in human the same way as it was seen in mice. The animals with genetically unleashed mTOR showed not only anemia (due to exhaustion of hematopoietic stem cells) but also grey hair and hunched backs.
A group of Russian scientists are taking the inhibitor of mTOR as a supplement. They hope to live longer and to stay younger as well as Mr. Thiel.
mTOR is a builder. So maybe the appearance of Mr.Thiel’s muscles will improve but the effectively working muscle needs also time to clean up and rebuild -the time out moment of mTOR inhibition.
In normal cell mTOR oscillates under direct control of day light, supported by chemical signaling connecting eyes-brain and body. The better synchronization, the healthier organism is. With age the synchronization is less efficient contributing to inflammation and cancer. So who will live longer?
Image is based on Heinrich Hoffman 1844 illustration to The Story of Augustus, who would not have any Soup.