Join us for a Science on Google+ HOA as we speak to Akinola Emmanuel and Dr shilpa keerthivasan about their recently published research on cancer signalling (http://stm.sciencemag.org/content/6/225/225ra28). We will discuss the basics of cancer signalling, explain the link between inflammation and cancer, and how their research identifies a novel role for immune cells in the development of colon cancer. This Pub Talks HOA will be part of a series in which we explain published research in a jargon-free manner that is understandable to the public.
This HOA will be hosted by Dr Buddhini Samarasinghe and you can tune in on Sunday March 23rd at 2 PM CDT/ 12PM PDT/ 7 PM GMT. The hangout will be available for viewing on our YouTube channel (https://www.youtube.com/ScienceHangouts) after the event.
Science on Google+ 
I’m looking forward to talking to Akinola Emmanuel in a real pub.
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Hopefully not before the HOA Chad Haney 😛
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I have to keep an eye on Akinola Emmanuel. The University of Chicago is known for being the place where fun goes to die.
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Chad Haney birthday pub?
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Yes! Pics or it didn’t happen 😛
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Here’s a quick primer on the basics of Wnt signalling for those of you who are interested to know more: http://goo.gl/9Z2Iji
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Thanks everybody for joining us for Pub talks regarding cancer signaling. Looking forward for wonderful discussion. Thanks Buddhini for the invitation.
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Sorry Buddhini Samarasinghe no pictures. Don’t worry, I didn’t get Akinola Emmanuel drunk.
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If you have any questions for our guests please leave them on the event page!
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Akinola Emmanuel is talking about epigenetic modifications on DNA when he refers to “imprinting”
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Are they any drugs known to bind to and inhibit beta-catenin or other key players in the Wnt pathway?
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There some work on Wnt/β-catenin inhibition in prostate cancer by trying to induce apoptosis.
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Thank you for joining us everyone! It was lots of fun to talk to shilpa keerthivasan and Akinola Emmanuel about their work!
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Letha McGarity We’ve used the Apc mouse model, but we’ve modified it to be specific either to T cells or epithelial cells so we can understand if the activation of Beta Catenin must be done in T cells or if it can be activated in epithelial cells in order for colitis to develop.
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Chad Haney I think the induction of apoptosis has the potential to be very beneficial because apoptosis has been shown to lead to the production of molecules that are important for regulatory T cell development. How would you make it specific though?
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That’s a tough question Akinola Emmanuel. As usual, it will probably work in mice and not in humans.
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Chad Haney very true, and that’s why the follow up is important. shilpa keerthivasan ‘s next step is looking into human regulatory T cells and understanding what genes are essentially malfunctioning. We’re trying to be specific by avoiding Beta Catenin and going after what it screws up in a particular cell.
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I’m looking forward to the follow up.
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Its was great experience.
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Science on Google+ It was great experience for us also. Highly recommended for all scientists.
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